منابع مشابه
Genetic Association Studies in Stroke
Background and Purpose—A large number of candidate gene association studies have attempted to identify genes implicated in stroke, but there have been few replicable and robust associations reported. Summary of Review—The skantness of replicable associations partly relates to poor study design. Important methodological considerations include adequate sample size, the selection of appropriate co...
متن کاملGenetic association studies.
To the Editor: I am delighted to see that Arteriosclerosis, Thrombosis, and Vascular Biology has taken the lead in initiating an open discussion about genetic association studies in such a prominent manner. As correctly pointed out in the editorial by Dr Hegele,1 the number of publications has exponentially increased in the last decade. Despite the intrinsic problems with this approach, this ex...
متن کاملGenetic association studies.
With the completion of the HapMap project1 and the development of technology that allows the examination of 1 million genetic polymorphisms at once, genetic association studies are becoming more comprehensive. This article first provides a brief overview of the rationale for genetic association studies; it then discusses the primary features differentiating genetic from standard association stu...
متن کاملGenetic association studies.
The widespread availability of DNA from large population studies, the development of rapid throughput genotyping assays, and the identification of numerous polymorphisms in genes of interest make it easier to perform genetic association studies in humans. We consider these studies appropriate areas of research in relation to atherosclerosis, thrombosis, and vascular biology. In this issue, Drs ...
متن کاملStatistical significance in genetic association studies.
Clinical & Investigative Medicine (CIM) is receiving an increasing number of reports of candidate-based association studies. The track record of such studies in the past has been poor: numerous genetic associations reported from candidate gene studies have not been replicated in later studies.1 The rise of the genomewide association study (GWAS) is changing this situation. A well-designed GWAS ...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2011
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbq074